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HIF-2α agonist 2
CAS No. 2750141-15-0
HIF-2α agonist 2( —— )
Catalog No. M36012 CAS No. 2750141-15-0
HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α. HIF-2α agonist 2 can promote the stability of the ARNT A/B ring in the 3z structure of HIF-2a-ARNT complex without cytotoxicity to 786-o-Reha-Luc cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 78 | Get Quote |
|
| 5MG | 116 | Get Quote |
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| 10MG | 187 | Get Quote |
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| 25MG | 365 | Get Quote |
|
| 50MG | 542 | Get Quote |
|
| 100MG | 759 | Get Quote |
|
| 500MG | 1557 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameHIF-2α agonist 2
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NoteResearch use only, not for human use.
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Brief DescriptionHIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α. HIF-2α agonist 2 can promote the stability of the ARNT A/B ring in the 3z structure of HIF-2a-ARNT complex without cytotoxicity to 786-o-Reha-Luc cells.
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DescriptionHIF-2α agonist 2 (compound 10) is a HIF-2α agonist with an EC50 value of 1.68 μM at the dose of 20 μM. HIF-2α agonist 2 is non-cytotoxic against 786-O-HRE-Luc cells. HIF-2α agonist 2 can be used for oxygen metabolism research.
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In VitroCell Viability Assay Cell Line:786-O-HRE-Luc cell line Concentration:0.003-20 μM Incubation Time:24 hours Result:Showed no cytotoxicity to 786-O-Luc cells.
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetHIF/HIF Prolyl-hydroxylase
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RecptorHIF | HIF/HIF Prolyl-Hydroxylase
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Research Area——
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Indication——
Chemical Information
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CAS Number2750141-15-0
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Formula Weight416.09
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Molecular FormulaC13H8Br2N2O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (240.33 mM; Ultrasonic (<60°C)
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SMILESN(C=1C=2C(S(=O)(=O)N1)=CC=CC2)C3=CC(Br)=CC(Br)=C3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yu Y, et al. Insight into the binding mode of HIF-2 agonists through molecular dynamic simulations and biological validation. Eur J Med Chem. 2021 Feb 5;211:112999.?
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